Skin type dc2/15/2024 ![]() ![]() Therefore, CD103 −DDCs act as sentinels against skin invasion that respond with increased cellular migration and antigen trafficking from the skin to the dLNs. Both stresses increased the turnover of CD103 −DDCs within the dLN, causing these cells to die within one day of arrival. ![]() Tape stripping (mechanical injury) induced a long-lasting four-fold increase in CD103 −DDC migration to the dLN and accelerated the trafficking of exogenous protein antigens by these cells. Application of a skin irritant (chemical stress) induced a transient >10-fold increase in CD103 −DDC migration from the skin to the dLN. Langerhans cells and CD103 +DCs, including Langerin +CD103 +dermal DCs (DDCs), remained in the dLN for 4–4.5 days after migration from the skin, while CD103 −DDCs persisted for only two days. By exposing the skin or dLN of these mice to violet light, we were able to label and track the migration and turnover of endogenous skin-derived DCs. To quantify the spatiotemporal regulation of skin-derived DCs in vivo, we generated knock-in mice expressing the photoconvertible fluorescent protein KikGR. Allergy to selected cosmetic ingredients.Skin-derived dendritic cells (DCs) play a crucial role in the maintenance of immune homeostasis due to their role in antigen trafficking from the skin to the draining lymph nodes (dLNs). Moisturizing different racial skin types. Chemical peels for melasma in dark-skinned patients. Ethnic skin types: Are there differences in skin structure and function? The role of moisturizers in addressing various kinds of dermatitis: A review. Vegetable butters and oils as therapeutically and cosmetically active ingredients for dermal use: A review of clinical studies. Hyaluronic acid: A key molecule in skin aging. Skin acceptability of a cosmetic moisturizer formulation in female subjects with sensitive skin. How much do we really know about our favorite cosmeceutical ingredients? Special considerations for common skin disorders. Dermatologic conditions in skin of color: Part I. Sensitive skin: Review of an ascending concept. Topical vitamin C and the skin: Mechanisms of action and clinical applications. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. ![]()
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